The “fruit of the vine,” as wine is poetically called, is a rare synthesis of nature and Judaism's philosophy of free will. Everything in a person's life can be used for good or for bad. For instance, wealth can be hoarded or used to help others. This is exactly the reason that wine is used for Kiddush. Through drunkenness, wine can easily lead one away from Godliness, so instead we bless it and use it to sanctify God's name. In moderate amounts, wine leads to pleasant happiness. In excess, however, wine can lead to anger, the total loss of inhibition, depression, etc.
From a less philosophical
*Wine is the ideal. However, if one does not like wine or may not drink wine, grape juice may be used. For the daytime Kiddush, one may also use other beverages such as whiskey.
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